This paper outlines a comprehensive and flexible analytical conceptual framework to be used in the production of a case study series. The cases are expected to identify factors that help or hinder rigorous impact evaluations (IEs) from influencing policy and improving policy effectiveness. This framework has been developed to be adaptable to the reality of developing countries. It is aimed as an analytical-methodological tool which should enable researchers in producing case studies which identify factors that affect and explain impact evaluations’ policy influence potential. The approach should also enable comparison between cases and regions to draw lessons that are relevant beyond the cases themselves.